Snake venom has many bioactive components, mainly including protease and polypeptide
It accounts for about 90%~95% of the dry weight of snake venom [l
With the continuous development of technology, many biological protein active ingredients in snake venom are gradually
It has been isolated and purified, and people have
Carry out in-depth research on it with a view to applying the effective medicinal ingredients in snake venom to people
In the treatment of similar diseases. Currently, the active ingredients of effective drugs contained in snake venom
The drug research and clinical application carried out are mainly focused on antithrombotic, hemostatic and hypoglycemic
Pressure, anti-cancer and painkillers.
L Antithrombotic drugs
The snake venom protease with anti-thrombotic and thrombolytic effects mainly includes Ancelor
Enzyme (hoe crod), batmxobin, defibrase (de coerase) and Agkistrodon acutus
Enzyme (acutobin). The first three belong to snaI [e venom
Thmmbin like enzynles, s Ⅷ. E), sVTLE is serine protease, the same as
It has arginine esterase and amidase activity - 1. Snake venom thrombin-like enzyme
It acts on fibrinogen to release fibrinogen A or B, thus
It can coagulate the polymerization of fibrin monomer head and tail, because it shows thrombin
Function and is called thrombin-like. At the same time, snake venom thrombin-like enzyme cannot be found in humans
Activates coagulation factor x Ⅲ in vivo, and the fibrin monomer produced by its hydrolysis can
Head and tail polymerization, but can not produce side chain cross-linking, which is easy to be damaged by natural reticuloendothelial system
The plasma fibrinogen level is reduced due to phagocytosis or degradation by fibrinolytic system
It is in a benign fibrinolytic state, so it shows anticoagulation and depression in the body
Fibrillation H1. Agkistrodon acutus enzyme belongs to fibrinolytic enzyme, which is fibrinolytic
The abbreviation of the enzyme [Erin (ogen) ol "icenzyme, FLE] can be divided into single-chain
Zinc metalloproteinase and single-chain or double-chain serine protease, mostly zinc metal egg
White enzyme. Snake venom fibrinolytic enzyme does not need activation of activator, and can directly cut fibers
The protein (protogen) generates hemofibrin, so it will not cause aggregation “J.
From the venom of Agkistrodon halys (e.g. sek, № r [md ∞ to, ship) in Malaysia
The isolated ankylose was the first to be used in the clinical treatment of thrombotic diseases
SVTLE drug. 6 J。 After the development of Ancelose, it was once studied by many countries
Researchers believe that sV’11E is the most promising drug for the treatment of thrombotic diseases,
In addition to being used for the treatment of peripheral thrombosis, it can also be used for the treatment of deep venous thrombosis and central venous thrombosis
Pulse thrombosis also has curative effect “J. By the 1990s, many countries and regions
Qu Du is very interested in the treatment of acute cerebral ischemia and stroke with aclase, and
Fund project: Military Medical Science and Technology Youth Cultivation Project (13QNP068); The whole army “12
5 “general medical research project (cwslJ280); Chengdu Military Region “12th Five-Year Plan” Medical Research
Key projects (B12026); General medical research project of Chengdu Military Region during the 12th Five-Year Plan
(C12062)
Author’s unit: 650032 Kunming, Chengdu Military Region Center for Disease Control and Prevention (Zhang Zhixiao,
Hu Tingsong, Cui Qinghua, Zheng Ying, Fan Quanshui); Pathogens, School of Basic Medicine, Youjiang Medical College for Nationalities
Biology and Immunology Teaching and Research Office (Xie Zhenfeng)
Corresponding author: Fan Quanshui, E-mail: fqsl68@126 ．com
Several small-scale clinical application studies have been carried out. Initial drug use evaluation index
In addition, Ancelose can be used in the clinical treatment of patients with acute ischemic stroke in the early stage
It shows good curative effect. After that, with large-scale randomized double-blind, placebo pair
According to the clinical trial, she, etc. For 2613 cases of acute
The drug treatment results of patients with sexual ischemic stroke confirmed that the patients in the cloroxobin group
The survival rate was significantly increased, but the risk of intracranial hemorrhage was also increased. After that
The clinical trial of 1222 patients with acute ischemic stroke confirmed that after 3 hours
Ancelose is not recommended for treatment. 1…。 The United States and Canada published in 2009
500 strokes involving 12 countries and regions including Canada and Australia
suffer from
Post time: Feb-26-2023