[Abstract] Objective: To evaluate the safety of hemocoagulase (HCA) from Agkistrodon acutus after minimally invasive percutaneous nephrolithotomy (MPCNL). Methods: 40 patients were selected, who were not given hemostatic drugs before and during the operation, and were continuously injected with Haemocoagulase (HCA) from Agkistrodon acutus 1 to 3 days after the operation. The coagulation function and safety indexes of the body were observed before the operation and on the third day after the administration. Result: There was no statistically significant difference in vital signs, liver and kidney function, and coagulation related indicators between the 40 patients before surgery and on the 3rd day after administration (P>0.05). Conclusion: It is safe to use Haemocoagulase from Agkistrodon acutus to reduce bleeding after minimally invasive percutaneous nephrolithotomy.
Post time: Jul-21-2023