Objective To study the anti-angiogenesis effect of fraction K from Guangxi Agkitrodon Acutus venom. Methods The inhibitory effects of fraction K against endothelial cell line ECV304 in vitro was measured by MTT, adhesion of ECV304 cells to fibronectin (FN ) cell by fraction K was observed. The anti-angiogenesis effect in vivo was evaluated by chick embryo chorioallantoic membrane ( CAM) assay. Results The proliferation of endothelial cell line ECV304 was inhibited significantly by fraction K in a time and dose dependent manner. Fraction K also inhibited endothelial cell adhesion to FN and tubule formation in CAM. Conclusion Fraction K has an anti-angiogenesis activity.%
Post time: Nov-20-2022