Objective To observe the effect of Haemocoagulase from Agkistrodon acutus on intraoperative hemorrhage in craniocerebral surgery. Methods 46 patients undergoing craniocerebral surgery were randomly divided into two groups according to the order of admission: the coagulase group and the control group, 23 patients in each group. Hemocoagulase group was routinely given craniocerebral operation, and 2 U of haemocoagulase from Agkistrodon acutus for injection was injected intravenously 30 minutes before operation and on the first day after operation. The control group was treated with the same medication as the hemagglutination enzyme group during and after the operation, but the injection of hemagglutination enzyme of Agkistrodon acutus was not given before the operation. The intraoperative bleeding and drainage volume 24 hours after operation were observed in the two groups. Results The amount of intraoperative bleeding (431.1 ± 20.1) ml and the amount of postoperative drainage (98.2 ± 32.0) ml in the hemagglutination enzyme group were significantly less than those in the control group (622.0 ± 55.6) ml and (140.1 ± 36.0) ml (P<0.05). Conclusion Intravenous injection of Haemocoagulase from Agkistrodon acutus before operation can reduce the incidence of postoperative complications by reducing the amount of bleeding. It is worth popularizing and applying widely in clinical practice.
Post time: Dec-16-2022