The domestic venom of Agkistrodon acutus was used to screen opioid receptor agonists to find new non addictive analgesic drugs Methods The electrophoretic pure sample was obtained from the venom of Agkistrodon acutus by chromatographic separation, and the effect of the sample on CHO was determined by using a microphysiological analyzer- μ At the same time, the activity of receptor cells was tested by animal hot plate method for analgesia, and the tail raising and jumping addiction tests were conducted in mice. Results An electrophoretic pure protein with a molecular weight of 12000 was obtained from the venom of Agkistrodon acutus, and- μ The affinity activity of receptor cells is very high, and the component has high analgesic effect on mice, no addiction, and no toxicity. Conclusion The component has good clinical application value
Post time: Dec-02-2022