Well-designed Small Metabolites And Peptides In Snake Venoms - Snake Venom Application Anti-cancer effect – Longshe
Well-designed Small Metabolites And Peptides In Snake Venoms - Snake Venom Application Anti-cancer effect – Longshe Detail:
With the development of science and technology, more and more people have studied snake venom
Many single components have anticancer activities, and their mechanisms of action can be broadly divided
There are three aspects :
(1) ionin, its main function is to inhibit tumor
Vascular hyperplasia and adhesion between tumors;
(2) Cytotoxin, directly
It is used for killing cells by cancer cell membrane;
(3) Inducing apoptosis. when
Anti-cancer properties have also been previously found in pit viper venom. Duan Tao et al from Guangxi Jian
A cytotoxin I 3-H3 was isolated from the venom of agkistrodon halys and cultured in vitro
Human lung cancer cell line (A549), human gastric cancer cell line (B G C) and human nasopharyngeal carcinoma cell line (KB)
To use. Zhang Liang et al. isolated two anticancer components A from venom of Agkistrodon agkistrodon in southern Anhui
CTX-6 and ACTX-8 were tested against human lung cancer cell line (A 5 4)
9) The most sensitive, and good thermal stability. Lei Danqing and others from agkistrodon venom
A small molecule polypeptide K component was isolated from chicken embryo allantoic membrane
The role of angiogenesis has the potential to become more active against tumor angiogenesis
Peptide. Li Yingxin et al studied the effect of K component on human ovarian cancer cells cultured in vitro
The proliferation of strain A 277 80 was significantly inhibited, and the mechanism was possible
It is associated with anti-cell adhesion and inducing apoptosis.
4) Other physiological effects
Agkistrodon venom has also been found to improve microcirculation, reduce blood pressure, and reduce alertness
Toxic effects. Linzhentao and others were isolated from agkistrodon venom with dilation
Microvascular, the component of lowering blood pressure, its mechanism of action may be related to
Inhibits platelet aggregation and inhibits platelet calcium influx and calcium mobilization, thereby
Decrease the concentration of free calcium ion in platelet cytoplasm. Li Wande et al
It was found that agkistrodon viper venom had a rapid excitatory postsynaptic effect on the sympathetic nerve of toad
Potential (F -EPS P) has inhibitory effect. Chen Xingzhi et al. found that in
He-la cells and TH P-1 cells of Agkistrodon halys venom
The percentage of tachyzoites infected with T. gondii was significantly increased.
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